Fig. 1

Schematic illustration of the study. Exosomes were first loaded with doxorubicin and Rose Bengal (RB) via sonication, followed by surface decoration with PEG2000-TK-CP05 for stealth. Under 532 nm laser local irradiation on the tumor region, RB-generated ROS cleave the TK and induce the burst release of exosomes. The local delivery of Doxorubicin (Dox), resulting in enhanced cancer therapy via multiple mechanisms