Skip to main content
Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: Metformin and histone deacetylase inhibitor based anti-inflammatory nanoplatform for epithelial-mesenchymal transition suppression and metastatic tumor treatment

Fig. 3

HAOPTs targeted orthotopic breast tumor tissues. A Fluorescent images of the cellular uptake of free coumarin-6, OPTs-Cou, DexOPTs-Cou and HAOPTs-Cou in 4T1 tumor cells. Blue, Hoechst 33,258; green, coumarin-6. Scale bar, 50 µm. B Quantitative analysis of the cellular uptake in 4T1 cells. C Plasma DiR concentration–time curves after intravenous injection of free DiR, OPTs-DiR, DexOPTs-DiR and HAOPTs-DiR in S-D rats. Data were represented as mean ± SD (n = 3), ****P < 0.0001. D Representative ex vivo fluorescence images of hearts, lungs, livers, kidneys, spleens and tumors after 24 h. E Semi-quantitative analysis of the fluorescence intensity of ex vivo tumors and other organs. Data were represented as mean ± SD (n = 3), ****P < 0.0001

Back to article page