Fig. 8

HAOPTs inhibited primary tumor growth and lung metastasis formation in orthotopic breast tumor mice. A Treatment schedule and timeline for treatments of free OA-Met, free pro-DHA, free triptolide, HAOPs (27.9 mg/kg), HAOTs (25.9 mg/kg), DexOPTs (30.2 mg/kg) and HAOPTs (28.6 mg/kg). B Primary tumor growth curves of mice in 27 days. C The analysis of ex vivo tumor weights after all treatments. Data were represented as mean ± SD (n = 5), *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. D Lung ex vivo images with bioluminescent signals after all treatments. E Lung ex vivo semi-quantitative analysis with bioluminescence. Data were represented as mean ± SD (n = 5), *P < 0.05, ***P < 0.001. F Kaplan–Meier survival analysis of mice