Fig. 6

In vivo biodistribution and pharmacokinetics of cRGD-Exo/TP. A The in vivo fluorescence images of tumor-bearing mice treated with DiR-labeled Exo/TP or DiR-labeled cRGD-Exo/TP for 24 h. B The ex-vivo fluorescence images of primary organs, tumor tissues, and blood captured at 24 h after administration. C The fluorescence intensity in tumor tissues at different times. D TP concentration–time profiles of the TP solution, Exo/TP, and cRGD-Exo/TP groups in tumor-bearing mice. E TP concentration in tumor tissues at predetermined times of TP solution, Exo/TP, and cRGD-Exo/TP groups. *p < 0.05, **p < 0.01, ***p < 0.001