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Fig. 7 | Journal of Nanobiotechnology

Fig. 7

From: αvβ3 integrin-specific exosomes engineered with cyclopeptide for targeted delivery of triptolide against malignant melanoma

Fig. 7

Anti-melanoma efficacy in vivo. A Schematic diagram of animal grouping and manipulations. B Representative images of the harvested xenograft tumors of the normal saline, cRGD-Exo, TP solution, Exo/TP, and cRGD-Exo/TP groups. C Tumor volume of different groups at interval times. D Tumor weight of different groups at the endpoint of the experiment. E H&E (scale bar: 50 μm), TUNEL (scale bar: 50 μm), and Ki67 (scale bar: 20 μm) results of tumor tissues in different groups. F Semiquantitative analysis of TUNEL-positive cells. G Semiquantitative analysis of IOD in Ki67 staining; H The survival time of tumor-bearing mice with different treatments. *p < 0.05, **p < 0.01, ***p < 0.001

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