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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Directing ricin-based immunotoxins with targeting affibodies and KDEL signal peptide to cancer cells effectively induces apoptosis and tumor suppression

Fig. 6

In vivo therapeutic efficacy of AlBD/HER2Afb/RTA-KDEL and other AlBD-containing RITs in SK-BR-3 tumor-bearing mice. A Tumor volumes and B body weights were measured with a caliper and scaler, respectively. C Weight of biopsied tumors were measured and D a picture of the biopsied tumors are shown. E The hearts, kidneys, livers, lungs, spleens, and tumors collected from sacrificed mice treated with PBS, AlBD/HER2Afb/RTA-KDEL, AlBD/HER2Afb/RTA, or AlBD-SC-RTA-KDEL were fixed, embedded in paraffin, and sectioned. The organ tissue and tumor sections were stained with hematoxylin and eosin (H&E) and extra tumor sections were independently stained with TUNEL. Images were captured using an Olympus virtual microscope. Scale bar, 100 μm at spleen and 50 μm at others. All data shown in A–C are the means ± SD; n = 4 per group; **p < 0.01; ns not significant

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