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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: An ischemia-homing bioengineered nano-scavenger for specifically alleviating multiple pathogeneses in ischemic stroke

Fig. 4

BBB-crossing and ischemia-homing capabilities of the TPC@M2 NPs. a Schematic of the transwell assay for constructing the BBB model in vitro. b CLSM images of the PC-12 cells treated with different treatments, scale bar: 25 μm. c Diagram of BV-2 cells and PC-12 cells co-cultured in a transwell dish. d CCK-8 assay of PC-12 cells after cocultured with BV-2 cells which pre-treated with the TPC@M2 NPs (n = 6). e Optical imaging of MCAO rats and the main tissues after injection of DIR/ TPC/DIR and TPC@M2/DIR (with the same dosage of DIR) (n = 3). Results are presented as means ± s.d. *P < 0.05, **P < 0.01, and ***P < 0.001 determined by Student’s t-test

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