Exosomes in the tumor microenvironment of sarcoma: from biological functions to clinical applications

Ye, Huali; Hu, Xin; Wen, Yang; Tu, Chongqi; Hornicek, Francis; Duan, Zhenfeng; Min, Li

doi:10.1186/s12951-022-01609-0

Journal of Nanobiotechnology

Table 3 Studies on the diagnostic and prognostic values of exosomes

From: Exosomes in the tumor microenvironment of sarcoma: from biological functions to clinical applications

Sarcoma type	Exosome source	Exosomal cargos	Sample source	Clinical application	References
MFS	Serum	miR-1260b	15 patients, 5 non-sarcoma patients, 9 healthy controls	Diagnostic biomarker	[67]
DSRCT	Serum	miR-34a-5p, miR-22-3p, miR-324-5p	3 patients, 4 healthy controls	Diagnostic biomarker	[74]
OS	Serum	miR-195-3p	25 patients, 10 healthy controls	Diagnostic biomarker	[77]
OS	Serum	miRNAs	5 patients	Diagnostic biomarker	[78]
DDLPS	Serum, tissue	miR-1246, -4532, -4454, -619-5p, and -6126	22 OS, 17 DDLPS, 3 EWS patients	Diagnostic biomarker	[79]
SS	Serum	miR-92b-3p	12 SS patients, 12 benign tumor patients, 12 healthy controls	Diagnostic biomarker	[80]
RTK	Serum	miR-214-3p	10 patients, 10 healthy controls	Diagnostic biomarker	[81]
OS	Serum	Proteins	8 patients, 5 controls with fracture, 5 healthy controls	Diagnostic biomarker	[83]
EWS	Serum	CD99/MIC2, NGFR	10 patients, 6 healthy controls	Diagnostic biomarker	[84]
GIST	Serum	KIT, SPRY4	9 patients, 9 healthy controls	Diagnostic and prognostic biomarker	[85]
OS	Serum	PD-L1, N-cadherin	70 OS patients, 9 benign tumor patients, 22 healthy controls	Diagnostic biomarker	[86]
OS	Serum	Proteins	20 lung metastasis patients, 20 non-metastasis patients, 12 healthy controls	Diagnostic biomarker	[87]
ARMS, SS	Serum	Fusion transcripts	65 ARMS patients, 15 SS patients	Diagnostic biomarker	[89]
OS	Serum, tissue	lncRNA CASC15	Sera from 5 patients and healthy controls; 30 OS specimens, 30 normal bone tissues	Diagnostic biomarker	[90]
OS	Serum	hsa-circ-103801	43 patients, 5 healthy controls	Prognostic biomarker, chemoresistance↑	[91]
OS	Tissue	lncRNA SNHG17	5 pairs of tumor and tumor-free tissues	Prognostic biomarker	[75]
OS	Serum, tissue	miR-25-3p	Sera from 10 patients and 10 healthy controls; 45 biopsy specimens	Prognostic and diagnostic biomarker	[76, 93]
OS	Serum, tissue	SENP1	Sera from 146 patients; 60 pairs of tumor and tumor-free tissues	Prognostic biomarker	[92]
OS	Serum	Alpha-2-macroglobulin, protein S, complement C2	\	Prognostic biomarker, chemoresistance↑	[94]
OS	Serum	lncRNA ANCR	10 patients, 10 chemosensitive controls	Prognostic biomarker, chemoresistance↑	[95]

MFS, myxofibrosarcoma; miR, microPNA; DSRCT, Desmoplastic small round cell tumor; OS, osteosarcoma; DDLPS, dedifferentiated liposarcoma; EWS, Ewing’s sarcoma; SS, synovial sarcoma; RTK, rhabdoid tumor of the kidney; NGFR, nerve growth factor receptor; GIST, gastrointestinal stromal tumor; KIT, tyrosine kinase receptor; SPRY4, Sprouty homolog 4; PD-L1, programmed death-ligand 1; ARMS, alveolar rhabdomyosarcoma; lncRNA, long noncoding RNAs; CASC15, cancer susceptibility 15; hsa, homo sapiens; SNHG17, Small nucleolar RNA host gene 17; SENP1, sentrin SUMO-specific protease 1; ANCR, Angelman syndrome chromosome region

Back to article page

ISSN: 1477-3155

Contact us

Submission enquiries: journalsubmissions@springernature.com