Table 4 Studies on exosomes as potential delivery vectors in sarcoma treatment
Sarcoma type | Target cells | Exosome source | Exosomal cargos | Loading methods | Mechanisms | Loading efficiency | References |
|---|---|---|---|---|---|---|---|
OS | Sarcoma cells | MSCs | Doxorubicin | Co-incubation | Nucleic acid synthesis ↓ | 12% | [98] |
OS | Sarcoma cells | MSCs | miR-143 | Lipofection | Cell migration ↓ | Not mentioned | [99] |
OS | Sarcoma cells | OS cells | lncRNA MEG3 | Lipofection | Sponging miR-185-5p | Not mentioned | [100] |
FS | Immune cells | Macrophages | HSP70 | Incubation at 42℃ | Immune response ↑ | Not mentioned | [101] |
OS | Sarcoma cells | MSCs | miR-101 | Lentiviral transduction | Cell migration ↓ | About 48% | [108] |
OS | Sarcoma cells | OS cells | miR-371b-5p | Co-incubation | Cell proliferation and migration ↓ | Not mentioned | [109] |