Fig. 11

Application of inorganic nanocarriers based on IONPs and CDs for targeting brain tumor: A Schematic illustration of the design of the hybrids based on IONPs and corresponding TEM, MR, and PET-CT images demonstrating the delivery efficacy of IONPs to the brain (scale bar = 50 nm, inset: scale bar = 16 nm). Adapted with permission from Ref. [323], B Schematic illustration of overcoming the BBB using an adjustable RF field to perform hyperthermia with commercially available IONPs (injected into the external carotid artery). MR and fluorescent images showing the delivery of IONPs to the mouse brain. Adapted with permission from Ref. [324], C Scheme of synthesis and TEM image of hybrids based on CDs. Ex vivo analysis of the main organs (the brain, heart, liver, spleen, lungs, and kidneys) of mice after a 30-min intravenous injection, demonstrating the accumulation of nanohybrids in the brain (scale bar = 50 nm). Adapted with permission from Ref.[333]