Fig. 9
Application of SiO2-based NPs for targeting brain tumor: A TEM images of IONPs@SiO2 NPs with corresponding macroscopic ex vivo evaluation of their therapeutic efficiency against GBM tumors (scale bar = 100 nm). Adapted with permission from Ref. [279], B PET-CT imaging of radiolabeled core–shell SiO2 NPs showing clear accumulation of radionuclide signal in the brain tumors with corresponding histological and fluorescent analysis of NPs accumulation in the brain. Adapted with permission from Ref. [280]