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Fig. 1 | Journal of Nanobiotechnology

Fig. 1

From: Vasorin-containing small extracellular vesicles retard intervertebral disc degeneration utilizing an injectable thermoresponsive delivery system

Fig. 1

Diagrammatic sketch of hydrogel fabrication and its utilization in intervertebral disc regeneration. (1) Workflow of hydrogel fabrication. (2) Mechanism scheme of EVs-mediated effects on NP cells. (3) Sustained EVs release in FEC hydrogel. (4) Application of EVs@FEC in ex vivo and in vivo disc degeneration model. FEC, composite hydrogel based on Pluronic F127 and decellularized NP tissues (dECM); EVs, extracellular vesicles; EVs@FEC, EVs encapsulated into FEC hydrogel; NP cells, nucleus pulposus cells

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Journal of Nanobiotechnology

ISSN: 1477-3155

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