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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: Cartilage targeting therapy with reactive oxygen species-responsive nanocarrier for osteoarthritis

Fig. 3

Up-regulation of Nrf2-HO-1 signaling by MSN-OL. A Clustering analysis of the differentially expressed genes (DEGs) in cartilages treated by OL or MSN-OL. B Gene Ontology analysis was performed to clarify the differences in biological process. C Five terms of interest with DEGs were analyzed. DH Western blot was used to determine the changes of Nrf2/HO-1 signaling pathway between different groups, respectively. (* indicated p < 0.05, ** indicated p < 0.01, *** indicated p < 0.001 in comparison with the OL in (C), and IL-1β or IL-1β + OL treatment group in the rest figures, respectively)

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