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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Cartilage targeting therapy with reactive oxygen species-responsive nanocarrier for osteoarthritis

Fig. 4

In vivo drugs release behaviours and biotoxicity. A The schematic of single intraarticularly injection test. B Fluorescence imaging were used to observe the MSN-OL degradation in the knee joint cavity. C Frozen slicing technology were used to trace the nanoparticle degradation within the cartilage. D, E Analysis results showed that MSN-OL degraded with time in the joint cavity but reached the peak within the cartilage after 2 weeks. F Representative images of heart, liver, and kidney H&E staining at 4 weeks, 8 weeks, and 12 weeks

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