Fig. 4
From: Cartilage targeting therapy with reactive oxygen species-responsive nanocarrier for osteoarthritis
In vivo drugs release behaviours and biotoxicity. A The schematic of single intraarticularly injection test. B Fluorescence imaging were used to observe the MSN-OL degradation in the knee joint cavity. C Frozen slicing technology were used to trace the nanoparticle degradation within the cartilage. D, E Analysis results showed that MSN-OL degraded with time in the joint cavity but reached the peak within the cartilage after 2Â weeks. F Representative images of heart, liver, and kidney H&E staining at 4Â weeks, 8Â weeks, and 12Â weeks