Table 1 Various MOF-based nanotherapeutics for cancer diagnosis
From: Application of MOF-based nanotherapeutics in light-mediated cancer diagnosis and therapy
Diagnostic agents | Active ingredient | MOFs | Light source | Applications | Refs. |
|---|---|---|---|---|---|
Gd(BDC)1.5(H2O)2 | Gd3+ | Gd(BDC)1.5(H2O)2 | – | MRI | [43] |
Gd-Ru | Gd3+ | Gd-Ru | – | MRI | [44] |
Mn-NMOF | Mn2+ | Mn-IR825 | – | MRI | [45] |
Mn-TCPP | Mn3+ | Mn-TCPP | – | MRI | [47] |
MIL-88A | Fe3+ | MIL-88A | – | MRI | [49] |
MIL-100 MIL-101 | MIL-100 MIL-101 | – | |||
Fe-MIL-100@PB | Fe3+ | Fe-MIL-100 | – | MRI | [50] |
NS@MOF-ZD2 | Fe3+ | MIL-101-NH2 | – | MRI | [51] |
FePt-MOFs-tLyp-1 | Fe3+ | MIL-101(Fe) | – | MRI/CT | [53] |
Fe-MIL-53-NH2-FA-5-FAM/5-FU | Fe3+ | Fe-MIL-53 | – | MRI | [54] |
Fe3O4@UiO-66 | Fe3O4 | UiO-66 | – | MRI | [55] |
Fe3O4@IRMOF-3 | Fe3O4 | IRMOF-3 | – | MRI | [56] |
Zr-UiO | Zr | Zr-UiO | X-ray | CT | [59] |
Hf-UiO | Hf | Hf-UiO | |||
UiO-PDT | Zr | UiO-66 | X-ray | CT | [60] |
Mn/Hf-IR825@PDA-PEG | Mn2+ Hf4+ | Mn/Hf-IR825 | X-ray | MRI CT | [61] |
Au@MIL-88(Fe) | Fe3+ | MIL-88(Fe) | X-ray | MRI, CT and PAI | [63] |
89Zr-UiO-66/Py − PGA-PEG-F3 | 89Zr | UiO-66 | X-ray | PET | [68] |
64Cu-ZIF-8@ DOX | 64Cu | ZIF-8 | X-ray | PET | [69] |
Zr-NMOF | TCPP | Zr-TCPP | Visible light (530Â nm) | Optical imaging | [73] |
nano-Yb-PVDC-3 | Yb3+ PVDC | Yb-PVDC-3 | NIR | Optical imaging | [77] |
H2L-MOF | H2L | H2L-MOF | NIR-I fluorescence (646Â nm) | Optical imaging | [79] |
MIL-53(Al)-NH2@RhB | RhB | MIL-53(Al)-NH2 | Fluorescent light (375Â nm) | Optical imaging | [80] |
PS@MOF-199 | TPAAQ | MOF-199 | White light (400–700 nm) | Optical imaging | [81] |
cal-TPP@(DCA5-UiO-66) | Fluorescent pyrene group | UiO-66 | Fluorescent light | Optical imaging | [82] |
UCNPs@MOF-DOX-AS1411 | UCNPs | MIL-100 (Fe) | NIR (980Â nm) | Optical imaging | [83] |
ZGGO@ZIF-8-DOX | PersL NPs | ZIF-8 | Fluorescent light | Optical imaging | [87] |
BQ-MIL@cat-fMIL | BP Quantum dot (BQ) | MIL-101-NH2 | Fluorescent light | Optical imaging | [88] |
MCH | Polydopamine modified hyaluronic acid | MIL-100 | NIR (808Â nm) | PAI | [94] |
(ZIF-8) derived carbon nanoparticles | – | ZIF-8 | NIR (808 nm) | PAI | [95] |
Cu-THQNPs | tetrahydroxyanthraquinone (THQ) | Cu-THQNPs | NIR II (1000–1350 nm) | PAI | [96] |
AuNR@- ZIF-8 | AuNR | ZIF-8 | NIR | PAI | [97] |
UCNPs@MIL-101(Fe) | Fe3+ UCNPs | MIL-101(Fe) | Luminescence | MRI and UCL | [100] |
MIL-100(Fe)@HA@ICG | Fe3+ ICG | MIL-100(Fe) | Luminescence | MRI, PAI and Optical imaging | [101] |
UCNPs@ZIF-8 | Ag2S Ag2Se | ZIF-8 | X-ray NIR (980Â nm) | CT, PAI and Optical imaging | [102] |