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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Enhanced natural killer cell anti-tumor activity with nanoparticles mediated ferroptosis and potential therapeutic application in prostate cancer

Fig. 5

Direct anti-cancer activity of combination treatment of NK cells and ferumoxytol in the PC-3 prostate cancer mice model. A. Experimental design of in vivo direct anti-cancer effects. B. Tumor growth curve of each group of treatment. The 6–8-week-old mice were randomly divided into 4 groups, DPBS, NK-92MI, NK-92MI + Fer and NK-92MI + Fer-aPDL1 group. NK cells were intratumorally injected into the PC3 tumors 4 times on days of 14, 18, 21 and 25. C. Representative images of tumors extracted after the experiment. D. Representative H&E images and TUNEL images of each treatment group (scale bar = 50 µm). E. Mean change of body weight of mice during the experiment for each group. The data represent mean ± s.d. (n = 4, 5) and statistical significance was analyzed by two-tailed Student’s t-tests. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

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