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Fig. 7 | Journal of Nanobiotechnology

Fig. 7

From: Huc-MSC-derived exosomes modified with the targeting peptide of aHSCs for liver fibrosis therapy

Fig. 7

Anti-fibrosis effect of HSTP1-Exos in vitro. A Visualization of lipid droplets by Oil Red staining in control, TGF-β, Blank-Exos, Lamp2b-Exos, and HSTP1-Exos-treated HSC-T6 cells at 24 h, 48 h, and 72 h. Scale bars: 20 µm. B The effect of exosomes on the HSC-T6 cells migration ability. The bar graph showed the results of analysis of the selected fields. C The effect of exosomes on the HSC-T6 cells proliferation. The bar graph depicted the cell count in each group at 72 h. The line chart showed the growth curve in each group. Scale bars: 1000 µm. D α-SMA immunocytofluorescence (green) in control, TGF-β, Blank-Exos, Lamp2b-Exos, and HSTP1-Exos-treated HSC-T6 cells at 48 h and 72 h. DAPI-stained nuclei (blue). Scale bars: 20 µm. E–G Western blot and relative protein expression qualification for the fibrotic proteins in HSC-T6 cells. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

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