Fig. 1From: Nanoengineering facilitating the target mission: targeted extracellular vesicles delivery systems designThe inherent homing mechanism of EVs. (1) Targeting molecules on the surface of EVs; (2) EVs have natural organ tropism; (3) EVs are phagocytosed by macrophages and endothelial cells when they enter the circulatory system; (4) EVs have an EPR effect in tumor cells due to their nanoscale diameterBack to article page