Fig. 5
Copyright 2021, Theranostics
Through the specific binding of the CP05 peptide to CD63 on the surface of EVs, the anti-angiogenic peptide was bound to the surface of EVs to generate an EXOKV11 delivery system that targets retinal blood vessels. A Schematic illustration of the preparation of EXOKV11. B Flow cytometry results show that 83.1% of KV11 peptides were bound to EVs based on the effect of CP05. C Mice were injected with KV11 and EXOKV11, respectively, and treated with FITC labeling observed fluorescence. D Under the action of CP05, EXOKV11 entered the eye more efficiently compared with KV11 alone. E In the OIR mouse model, retinal cryosections shows that EXOKV11 targets retinal vessels more efficiently [128].