From: The recent advancements in the early detection of cancer biomarkers by DNAzyme-assisted aptasensors
Biomarkers/Sample | Strategy | Sample | Aptamer Sequence (5′ → 3′) | NM/NPs | LOD | LR | Refs. |
---|---|---|---|---|---|---|---|
CEA | GQD/AuNPs/DNAzyme | Serum | CEAAptamerI:5′–NH2–ATACCAGCTTATTCAATT–3′ CEA Aptamer II: 5′–NH2–CCCATAGGGAAGTG GGGGA–3′ | GQD/AuNPs | 3.2 fg mL− 1 | 10 fg mL− 1 to 200.0 ng mL− 1 | [106] |
Exosomes | label-free DNAzyme/RCA/anti-CD63 | Plasma | AACCGCCCAAATCCCTAAGAGTC GGACTGCAACCTATGCTATCGTT GATGTCTGTCC | - | 9.54 × 102 mL− 1 | 4.8 × 103 to 4.8 × 106 exosomes mL− 1 | [107] |
MUC1 | PCN-224-PtNPs/dual-aptamer/HRP/GQH nanoprobe | Blood | AS1411 or MUC1 aptamer | PtNP | 6 cells mL− 1 | 20 to 1 × 107 cells mL− 1 | [108] |
P53 | G4-hemin DNAzyme, CS-G, AuNPs, and nicking endonuclease | Buffer | S1: NH2-C6-TTTTTTTCT GAC GCT GCT CAC G S2: SH-C6-TTTTTCGTGAGCAGC GTCAG | AuNPs | 3.0 × 1016 M | 1.0 × 1015-1.0 × 109 M | [113] |
HepG2 | G4/hemin/ TLS11a aptamer-AuNPs-HRP nanoprobe | Cell suspension | HS-(CH2)6-ACAGCATCCCCATGT GAACAATCGCAT TGTGATTGTTACG GTTTCCGCCTCATGGACGTG CTG | AuNPs | 30 cells mL− 1 | 102 to 107 cells mL− 1 | [115] |
ZnO@Au-Pd-HQ-HRP-G4/hemin/TLS11a aptamer nanoprobe | Blood | ZnO@Au-Pd | 10 cells mL− 1 | 102 to 107 cells mL− 1 | [116] | ||
Pd-Pt nanocage-HRP-cDNA/hemin/G4 DNAzyme/TLS11a aptamer | Pd-Pt nanocage | 5 cells mL− 1 | 10 to 1 × 106 cells mL− 1 | [117] | |||
MIL-101@AuNPs, hemin/G4 DNAzyme, TLS11a aptamer and HRP | MIL-101@AuNPs | 5 cells mL− 1 | 102 to 107 cells mL− 1 | [118] | |||
K562 cells | Super-sandwich G4 DNAzyme/cDNA | Cell suspension | ATCCAGAGTGACGCAGCAGATCAG TCTATCTTCTCCTGATGGGTTCCTATTTATAGGTGAAGCTGGACACGGTGG CTTAGT-(CH2)6-NH2 | - | 14 cells mL− 1 | 14 to 1.4 × 106 cells mL− 1 | [119] |