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Table 3 Performance of electrochemical-based DNAzyme-assisted aptasensors for cancer detection

From: The recent advancements in the early detection of cancer biomarkers by DNAzyme-assisted aptasensors

Biomarkers/Sample

Strategy

Sample

Aptamer Sequence

(5′ → 3′)

NM/NPs

LOD

LR

Refs.

CEA

GQD/AuNPs/DNAzyme

Serum

CEAAptamerI:5′–NH2–ATACCAGCTTATTCAATT–3′

CEA Aptamer II: 5′–NH2–CCCATAGGGAAGTG

GGGGA–3′

GQD/AuNPs

3.2 fg mL− 1

10 fg mL− 1 to 200.0 ng mL− 1

[106]

Exosomes

label-free DNAzyme/RCA/anti-CD63

Plasma

AACCGCCCAAATCCCTAAGAGTC

GGACTGCAACCTATGCTATCGTT

GATGTCTGTCC

-

9.54 × 102 mL− 1

4.8 × 103 to 4.8 × 106 exosomes mL− 1

[107]

MUC1

PCN-224-PtNPs/dual-aptamer/HRP/GQH nanoprobe

Blood

AS1411 or MUC1 aptamer

PtNP

6 cells mL− 1

20 to 1 × 107 cells mL− 1

[108]

P53

G4-hemin DNAzyme, CS-G, AuNPs, and nicking endonuclease

Buffer

S1: NH2-C6-TTTTTTTCT GAC GCT GCT CAC G

S2: SH-C6-TTTTTCGTGAGCAGC GTCAG

AuNPs

3.0 × 1016 M

1.0 × 1015-1.0 × 109 M

[113]

HepG2

G4/hemin/ TLS11a aptamer-AuNPs-HRP nanoprobe

Cell suspension

HS-(CH2)6-ACAGCATCCCCATGT

GAACAATCGCAT TGTGATTGTTACG

GTTTCCGCCTCATGGACGTG CTG

AuNPs

30 cells mL− 1

102 to 107 cells mL− 1

[115]

ZnO@Au-Pd-HQ-HRP-G4/hemin/TLS11a aptamer nanoprobe

Blood

ZnO@Au-Pd

10 cells mL− 1

102 to 107 cells mL− 1

[116]

Pd-Pt nanocage-HRP-cDNA/hemin/G4 DNAzyme/TLS11a aptamer

Pd-Pt nanocage

5 cells mL− 1

10 to 1 × 106 cells mL− 1

[117]

MIL-101@AuNPs, hemin/G4 DNAzyme, TLS11a aptamer and HRP

MIL-101@AuNPs

5 cells mL− 1

102 to 107 cells mL− 1

[118]

K562 cells

Super-sandwich G4 DNAzyme/cDNA

Cell suspension

ATCCAGAGTGACGCAGCAGATCAG

TCTATCTTCTCCTGATGGGTTCCTATTTATAGGTGAAGCTGGACACGGTGG

CTTAGT-(CH2)6-NH2

-

14 cells mL− 1

14 to 1.4 × 106 cells mL− 1

[119]