Fig. 3From: Cancer-derived small extracellular vesicles: emerging biomarkers and therapies for pancreatic ductal adenocarcinoma diagnosis/prognosis and treatmentSchematic of the formation and release of sEVs. MVB biogenesis is associated with ESCRT-dependent and ESCRT-independent pathways, agents such as ROCK, RAB, SNARE, Ca2+ affect the release of sEVs from cellsBack to article page