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Fig. 7 | Journal of Nanobiotechnology

Fig. 7

From: Targeted OUM1/PTPRZ1 silencing and synergetic CDT/enhanced chemical therapy toward uveal melanoma based on a dual-modal imaging-guided manganese metal–organic framework nanoparticles

Fig. 7

Biological activity of NPs. a–d Dose-dependent cell viability of OCM1a and IC50 values of NPs at 24 h. e, f Lnc OUM1 and PTPRZ1 expression in OCM1a after treated with NPs for 48 h. g, h EDU staining of OCM1a after treated with different NPs for 24 h. Scale bars, 200 μm. i, j Cell survival/death by live/dead staining (Calcein AM: live cells, PI: dead cells). Scale bars, 200 μm. k, l ROS production of OCM1a after treated with different NPs for 24 h. Scale bars, 100 μm. All data were obtained from at least three independent experiments (n ≥ 3), *** P < 0.001. **** P < 0.0001

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Journal of Nanobiotechnology

ISSN: 1477-3155

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