Scheme 1

GPRPP-Y8U@P played as an integrated nanomedicine for thrombus therapy. a The Y8U@P was fabricated by the double emulsion method, and the targeting peptide GPRPP was connected via EDC/NHS to synthesize GPRPP-Y8U@P. b The GPRPP-Y8U@P had surpassing characteristics in antithrombotic therapy and was confirmed by the six animal models: (1) Three flap animal models: Anterolateral thigh flap, McFarlane flap, Abdominal flap. The flap thrombus was established by applying ferric chloride to the donor's vessel. (2) Three thrombus animals: arterial thrombosis, venous thrombosis, and pulmonary embolism. (3) GPRPP-Y8U@P could intuitively detect thrombus by fluorescence imaging, utilizing photothermal, photodynamic, and UK trip effects that allowed for a firmly thrombolytic effect. (4) The thrombolytic procedure minimized bleeding risk due to controlled by Laser