Fig. 1
From: Advances in the modulation of ROS and transdermal administration for anti-psoriatic nanotherapies
Dysfunctional different cell types (KCs, skin-resident and -infiltrating immune cells function) mediate the propagation of inflammatory loops in EIME of psoriasis: turbulence of EIME evokes the initiation and chronic inflammation in psoriasis significantly associated with oxidative stress. Deleterious reactive metabolites ROS have a harmful role in inducing irreversible damage to these cells in EIME, thereby reprogramming their metabolic pathways involved in the development, proliferation, activation and function. Subsequently, intricately interwoven effects among these cells form clusters of inflammatory circuits in the pathophysiological EIME of cutaneous inflammation, ultimately giving rise to psoriasis