Fig. 7

Biosafety verification of PLP-RvD1. A, B Serum concentration of inflammatory cytokines (IL-1β, TNF-α) of healthy mice detected by ELISA assay at 3 d post administration of PBS or PLP-RvD1 (n = 6 per group). C, D ELISA assay of immune response indicated by serum level of general IgG and IgM of healthy mice with or without PLP-RvD1 treatment (n = 6 per group). E Evaluation of the effect of PLP-RvD1 on clotting function (n = 6 per group). Biochemical test of F liver and G renal function of healthy mice after PBS or PLP-RVD1 administered (n = 6 per group). H Histology characteristics of major organs of PBS or PLP-RvD1 treated healthy mice were detected by HE staining. Scalar bar, 100 μm. Results are presented as mean ± SD. ^NSP > 0.05