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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: AGuIX nanoparticles enhance ionizing radiation-induced ferroptosis on tumor cells by targeting the NRF2-GPX4 signaling pathway

Fig. 2

DNA damage in the breast cancer cells in the different treatment groups. A Reactive oxygen species (ROS) production of MDA-MB-231 breast cancer cells 24 h after irradiation. B Relative content of ROS of MDA-MB-468 breast cancer cells 24 h after irradiation. C Representative images of the comet assay of the MDA-MB-231 cells at 30 min postirradiation and 1 h postirradiation. D The quantitative statistical graph of olive tail moments showed DNA strand breaks in the MDA-MB-231 E The quantitative statistical graph of olive tail moments showed DNA strand breaks in the MDA-MB-468 breast cancer cells. F Representative images of the immunofluorescence analysis of the MDA-MB-231 cells at 2 h postirradiation and 24 h postirradiation. G Quantitative representation of the γH2AX foci in the activated MDA-MB-231 (> 10 foci per cell). H Quantitative representation of the γH2AX foci in the activated MDA-MB-468 cells. I Cell cycle phase distribution of the MDA-MB-231 cells under different treatment conditions. J Cell cycle phase distribution of the MDA-MB-468 cells under different treatment conditions. All data are represented as means ± standard errors of the means, n ≥ 3 independent replicates and P-values were calculated using two-tailed t-tests. A single asterisk indicates P < 0.05, two asterisks indicate P < 0.01, and three asterisks indicate P < 0.001

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