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Fig. 7 | Journal of Nanobiotechnology

Fig. 7

From: Exosomal miR-140-5p inhibits osteogenesis by targeting IGF1R and regulating the mTOR pathway in ossification of the posterior longitudinal ligament

Fig. 7

MiR-140-5p inhibits bone formation in vivo. a Diagram of the procedures of the bone formation experiment in vivo. b 3D-reconstructed images of scaffolds after 8 weeks. BV/TV c and BMD d of scaffolds were calculated by micro-CT scan among different groups treated with miR-140-5p-exo, miR-NC-exo, sponge-exo, or sponge-NC-exo. e Immunohistochemical staining of scaffolds. Scale bars = 10 μm. f Schematic diagram of the mechanism by which exosomal miR-140-5p from OPLL cells inhibited osteogenesis by targeting IGF1R and regulating the mTOR pathway. For each group, n = 5. *P < 0.05. All data are presented as the mean ± SD

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