Fig. 2

The pro-reparative phenotype of normal wildtype EVs is delayed in EVs from db/db mice. a Schematic of EV collection from sponge implants implanted in WT and db/db mice (i.e. Donor) followed by adoptive transfer to full thickness wounds into db/db mice (i.e. Recipient). b Kinetics of wound closure area following treatment with EVs enriched WT vs. db/db donor mice (2-way ANOVA of WT vs db/db high dose EV treated mice, p-value < 0.0001). Additional statistical analysis of wound closure efficiency is shown on c Day 1, d Day 3, e Day 7, f Day 10, and g Day 14 (Means + SD, p-value: *** < 0.001, ** < 0.005, * < 0.05). h Representative images of splinted wounds treated with EVs. i Representative hematoxylin and eosin staining of the injury site following treatment with WT vs. db/db EVs at 14 days (Scale bars, 0.5 mm)