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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: TiSe2-mediated sonodynamic and checkpoint blockade combined immunotherapy in hypoxic pancreatic cancer

Fig. 5

Analyses of the in vivo antitumor impact of combination TiSe2-mediated SDT plus anti-PD-1 treatment. a Schematic overview of the experimental approach used to evaluate the effects of TiSe2-mediated SDT and anti-PD-1 combination treatment in murine tumor models. b Representative images of mice at the experimental endpoint in the indicated treatment groups. c, f Primary tumor growth was monitored (c) and primary tumors were imaged in the indicated treatment groups, with distant tumor growth (e) and imaging (f) similarly being performed in these animals. g–j Representative flow cytometry plots and corresponding quantitative analyses of the infiltration of CD8+ T cells (CD45+CD8+) and CD4+ FoxP3+ T cells (CD45+CD4+FoxP3+) in distant tumors. SDT, sonodynamic therapy; US, ultrasound. Data are means ± SD (n = 5), and were compared via one-way ANOVAs with Dunnett’s post hoc test. **P < 0.01, ***P < 0.001 and ****P < 0.0001

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