A schematic illustration of the combined application of TiSe2-mediated SDT and anti-PD-1 immune checkpoint blockade for the treatment of pancreatic cancer. SDT, sonodynamic therapy; PD-1, programmed cell death protein 1; ICD, immunogenic cell death; DC, dendritic cell; APC, antigen-presenting cell; CRT, calreticulin; HMGB1, high mobility group box 1; ATP, adenosine triphosphate; TAAs, tumor-associated antigens