Fig. 2

Characterization of MSC-derived SyEV. a TEM image of the generated NV and SyEV. Scale bars, 500 nm. b The number of particles per one microgram of vesicular proteins (n = 3). Data are presented as the mean ± SEM. *P < 0.05 by unpaired two-tailed Student’s t-test. c Representative electropherograms of DNA molecules derived from SyEV in comparison to those from NV. Filled triangles indicate internal markers. d Venn diagram of MSC-derived NV and SyEV proteomes. The common proteins are divided into three groups (1.5-fold increase, 1.5-fold decrease, and no change) based on the relative protein abundance (n = 2). e Plot of the log2 value of the relative protein abundance from NV and SyEV. The solid line and dotted lines show no change and 1.5-fold change, respectively. f Different GO cellular components were compared between the NV and SyEV proteome groups. g Venn diagram of MSC-derived EV and SyEV proteomes. The common proteins are divided into three groups (1.5-fold increase, 1.5-fold decrease, and no change) based on the relative protein abundance (n = 2). h Plot of the log2 value of the relative protein abundance from EV and SyEV. The solid line and dotted lines show no change and 1.5-fold change, respectively. i Different GO cellular components were compared between the EV and SyEV proteome groups