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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Silver nano-reporter enables simple and ultrasensitive profiling of microRNAs on a nanoflower-like microelectrode array on glass

Fig. 5

The specificity and sensitivity of e-miRchip in detecting miR-21. a A schematic diagram for verification of the specificity of e-miRchip by three non-complementary sequences (a 3-base mismatched sequence and two random sequences) in comparison with the complementary sequence (DNA-21). b CVs of the electrooxidation process of e-miRchip in sensing DNA-21, 3 bases mismatched DNA-21 (Mismatch) and two random sequences (Random 1 and Random 2); the concentration of all tested sequences was at 100 fM. c The oxidation peak current obtained from b. d CVs of the electrooxidation process of e-miRchip in the presence of miR-21 at various concentrations from 1 fM to 10 pM. e The oxidation peak current obtained from d. f The calibration curve obtained by plotting the electrooxidation peak current with miR-21 concentrations. N ≥ 3 per group, ***p < 0.001, ****p < 0.0001

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Journal of Nanobiotechnology

ISSN: 1477-3155

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