Fig. 4
From: Cell membrane-coated human hair nanoparticles for precise disease therapies
Antibacterial activity of HNP@RAWM in vitro and in vivo. A Illustration and quantitative analyses (B) of the bacterial colonies of S. aureus incubated with HNP and HNP@RAWM with NIR irradiation (808 nm, 1.0 W/cm2, 5 min, scale bar = 2 cm, ***P < 0.001). C Illustration and quantitative analyses (D) of the bacterial colony of S. aureus incubated with HNP and HNP@RAWM without NIR irradiation. E SEM images of HNP and HNP@RAWM adhered to S. aureus (scale bar = 1 μm, red arrows: HNP; blue arrows: HNP@RAWM). F Skin lesion sizes and quantitative analyses of relative lesion sizes (I, J) at the S. aureus infection sites after being incubated by PBS, RAWM, HNP, and HNP@RAWM for 1 h before NIR irradiation (808 nm, 1.0 W/cm2, 5 min, scale bar = 2 mm, n = 3 in each group). G Photographs and quantitative analyses (K, L) of the bacterial colony of the S. aureus infected tibia after being incubated by PBS, RAWM, HNP, HNP@RAWM for 1 h before NIR irradiation (808 nm, 1.0 W/cm2, 5 min, scale bar = 2 cm) on day 0, 1, 4, 7. H The H&E staining of skin lesion size of the mice after different treatments (error bars represent the mean ± s.d., one-way ANOVA was used for multiple comparisons; scale bar = 200 μm, n = 3, ns P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001)