Fig. 10
From: Nanoparticle-mediated selective Sfrp-1 silencing enhances bone density in osteoporotic mice
Organs Toxicity. Representative semi-panoramic images in the three experimental groups, Control (0.9% saline solution), Apt-LPNPs-Cntrl and Apt-LPNPs-SFRP1, showing the histological structure of the liver, kidney, lung, spleen, heart and brain. All the organs analyzed showed normal tissue architecture with no apparent changes at the cellular level. Liver: Hv: hepatic vein, PV: portal vein, arrowheads: sinusoid capillaries. Kidney: CR: renal corpuscle, TCP: proximal convoluted tubule, TCD: distal convoluted tubule, arrowhead: renal capsule. Lung: A: artery, B: bronchiole, RB: respiratory bronchiole, AS: alveolar sacs, PA: pulmonary alveoli. Spleen: A: artery, RP: red pulp, WP: white pulp, arrowhead: splenic capsule. Heart: c: cardiomyocyte, E: epicardium, M: myocardium, arrowhead: intercalar disc. Brain: BF: basalforebrain, Hy: hippocampus, TC: telencephalic cortex, V: cerebral ventricles with choroid plexuses. Scale bars: liver, kidney, lung, spleen and heart: 80 µm. Heart insert: 15 µm. Brain: 150 µm