Fig. 7
From: Nanoparticle-mediated selective Sfrp-1 silencing enhances bone density in osteoporotic mice
Histology. Representative images showing the trabecular bone microarchitecture (A, upper line) and the cortical bone structure (A, bottom line) in the three experimental groups (SS, A-A-LPNPs control and A-A-LPNPs). B Images at high magnification, showing details of the osteosynthesis cellular activity in the A-A-LPNPs control and A-A-LPNPs groups. Observe the hypertrophic appearance of the osteoblasts (Ob) in the GapmeR-SFRP1 group, indicative of a higher synthesis activity, compared to the scares hypertrophic osteoblasts (Ob) in the A-A-LPNPs control. C Representative images with VOF staining technique, showing the mineralization degree in the three experimental groups. Observe the red-brown staining of the trabecular bone in the A-A-LPNPs group, indicative of a bone with a higher degree of mineralization compared to the control groups (SS and A-A-LPNPs control). BMa: bone marrow, CB: cortical bone, Ob: osteoblast, Oc: osteoclast; Ot: osteocytes, TB: trabecular bone. (A and B: H-Er; C: VOF). Scale bars: A upper line: 70 µm; bottom line: 60 µm. B 40 µm. C 50 µm