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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Synergetic delivery of artesunate and isosorbide 5-mononitrate with reduction-sensitive polymer nanoparticles for ovarian cancer chemotherapy

Fig. 4

In vivo imaging, therapy, and biocompatibility of PSSP@ART-ISMN. A In vivo fluorescence biodistribution of Cy5.5-labeled PSSP@ART-ISMN in SKOV3 tumor-bearing mice. B Tumor growth curves of SKOV3 tumor-bearing mice receiving different therapies (n = 5). Representative photographs (C) and tumor weight (D) after treatment for 12 days. (E) Mouse body weight change curve over the duration of treatment. F H&E and TUNEL staining analysis of tumor sections, scale bar: 200 µm. G Immunofluorescence staining of tumor sections. *P < 0.05, **P < 0.01, and ***P < 0.001; ns indicates P > 0.05

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