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Fig. 8 | Journal of Nanobiotechnology

Fig. 8

From: A split influenza vaccine formulated with a combination adjuvant composed of alpha-d-glucan nanoparticles and a STING agonist elicits cross-protective immunity in pigs

Fig. 8

NanoS100-SwIAV elicited antigen-specific IgG responses in the serum of vaccinated pigs. Five-week-old SPF pigs were administered twice ID/IM with NanoS100-SwIAV, Nano11-SwIAV or control NanoS100 and challenged at post-prime vaccination day 35 with SwIAV H1N1-OH7. Serum samples collected at DPC6 were analyzed by ELISA for detecting specific IgG antibody response against: A, B H1N1-OH7; C, D H1N2-OH10; and E, F H3N2-OH4 SwIAV. Data represent the mean value of 7–8 pigs ± SEM. Statistical analysis was performed by two-way ANOVA followed by Bonferroni post-test. Letters a, b and c refer to significance between NanoS100 + Challenge vs Nano11-SwIAV + Challenge, NanoS100 + Challenge vs NanoS100 + Challenge, and Nano11-SwIAV + Challenge vs NanoS100-SwIAV + Challenge respectively, at the indicated dilution

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Journal of Nanobiotechnology

ISSN: 1477-3155

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