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Table 2 Summary of significantly upregulated immune cells phenotypes

From: A split influenza vaccine formulated with a combination adjuvant composed of alpha-d-glucan nanoparticles and a STING agonist elicits cross-protective immunity in pigs

Immune cell phenotypes

ID Vaccination

IM Vaccination

Activated myeloid cells in TBLN MNCs [CD3CD172+CXCL10+]

**p < 0.01

 

IFNγ+ Effector memory T-helper/Memory cells in PBMCs [CD3+CD4+CD8α+CD8βCD27IFNγ+]

*p < 0.05

 

Total IL-17A+ T-helper/Memory cells in PBMCs [CD3+CD4+CD8α+CD8βIL-17A+]

**p < 0.01

 

IL-17A+ Central memory T-helper/Memory Cells in PBMCs [CD3+CD4+CD8α+CD8βCD27+IL-17A+]

**p < 0.01

 

IL-17A+ Effector memory T-helper/Memory cells in PBMCs [CD3+CD4+CD8α+CD8βCD27IL-17A+]

**p < 0.01

 

Total IL-17A+ CTLs in PBMCs [CD3+CD4CD8α+CD8β+IL-17A+]

p < 0.05

 

IL-17A+ Early effector CTLs in PBMCs [CD3+CD4CD8α+CD8β+CD27+IL-17A+]

p < 0.05

 

Total IL-17A+ CTLs in TBLN MNCs [CD3+CD4CD8α+CD8β+IL-17A+]

 

##***p < 0.01

IL-17A+ Late effector CTLs in PBMCs [CD3+CD4CD8α+CD8β+CD27IL-17A+]

 

***p < 0.001

  1. Only significantly enhanced immune cell subsets in NanoS100-SwIAV vaccinates compared to their non-adjuvanted counterparts in either ID or IM vaccinated SPF pigs at DPC6 were presented
  2. Asterisk represents significant difference between indicated groups (*/♯ p < 0.05, **/♯♯ p< 0.01, and ***/♯♯♯ p < 0.001)