A split influenza vaccine formulated with a combination adjuvant composed of alpha-d-glucan nanoparticles and a STING agonist elicits cross-protective immunity in pigs

Table 3 Experimental design to evaluate NanoS100-SwIAV vaccine efficacy in pigs

Five-week-old SPF pigs were administered twice ID/IM with NanoS100-SwIAV, Nano11-SwIAV or control NanoS100 and challenged at post-prime vaccination day 35 with SwIAV H1N1-OH7 and euthanized day post challenge [DPC] 6. Nasal swab, blood, lungs, TBLN, BAL cells were collected for the analysis. Three-eight pigs were used in each of the experimental groups
IM, Intramuscular; ID, Intradermal; NanoS100, Nano11 + ADU-S100; SwIAV, Swine influenza A virus H1N2 split antigen; Challenge, SwIAV H1N1 OH7

ISSN: 1477-3155