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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: A mitochondria-targeted molecular phototheranostic platform for NIR-II imaging-guided synergistic photothermal/photodynamic/immune therapy

Fig. 5

A The schematic diagram of 4T1 tumor-bearing mouse model and in vivo cancer therapy. B The body weights curves of mice in different groups. For irradiation groups, tumor regions were exposed to 808 nm laser at 1.0 W/cm2 for 10 min at 12 h post-injection. C IR thermal images of 4T1 tumor-bearing mice after intravenous injection of PBS, FEP or FEPT for 12 h and then treated with 808 nm laser irradiation (1.0 W/cm2, 10 min). D Photographs of tumors. E Tumor weights of different treated groups. G H&E, TUNEL, immunohistochemical analysis (IHC) of Ki-67 and cleaved caspase-3 in tumor tissues collected at 15 days post PTT/ PDT treatment. F Relative tumor growth curves of mice in different groups. V0: tumor volumes in the irradiated PBS-treated group at day 0, V: tumor volumes at different times. Positive signals in IHC staining are brown and the blue signal are nuclei. Apoptotic cells in TUNEL staining are green fluorescence, and the nuclei are stained with Hoechst33258. Scale bar: 50 μM. Error bars: mean ± SD (n = 3). *p < 0.05; **p < 0.01; ***p < 0.001

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