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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: Bone marrow-targetable Green Tea Catechin-Based Micellar Nanocomplex for synergistic therapy of Acute myeloid leukemia

Fig. 2

In vitro anti-leukemic effect. A Cytotoxicity of Sora-MNC and free sorafenib on MOLM-14 and MV-4-11 cells. Mean ± SD (n = 4). B Combination index plot. Colony formation of C MOLM-14 and D MV-4-11 cells treated with Sora-MNC, free sorafenib or HA-EGCG at equivalent doses. The dose of sorafenib for MOLM-14 and MV-4-11 cells was 50 and 200 nM, respectively. The right panels show the colonies formed after 14 days of culture. Mean ± SD (n = 3); ***P < 0.001. E Viability of MOLM-14, MV-4-11 and patient-derived AML cells treated with free sorafenib at varying concentrations. F Viability of patient-derived AML cells and bone marrow stromal cells treated with Sora-MNC or free sorafenib at varying concentrations. Mean ± SD (n = 4)

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