Fig. 8

PTPN alleviated myocardial infarction and promoted angiogenesis. a Animal experiment timeline. b Representative photographs of infarcted area with PRS staining (n = 7). Black lines indicated infarct zone, black frame indicated infarcted zone and blue frame indicated infarcted border zone. Scale bar = 1 mm. c, d CD31 expression in infarcted zone (c) and infarcted border zone (d) by immunohistochemical staining with different treatments (n = 7). Scale bar = 20 μm. Quantitative analysis of infarct size (e); CD31 + capillary density per field in infarcted zone (f) and infarcted border zone (g). Serum CK-MB (h), LDH (i) and MDA (j) levels (n = 7). Data are presented as mean ± SEM. Statistical analysis was via one-way ANOVA with GraphPad Prism 8.0; ns: not significant; *p < 0.05; **p < 0.01 and ***p < 0.001