Fig. 4
Multiplexed antibody neutralizing test against various variants for post-infection individuals. a Neutralizing effectiveness of IgG and IgM were evaluated by Wild-type recovered-individual sera against Wild-type S1. b Neutralizing effectiveness of IgG and IgM were evaluated by Delta recovered-individual sera against Delta S1. c Neutralizing effectiveness of IgG and IgM were evaluated by Omicron recovered-individual sera against Omicron S1. d The cross-neutralizing capacity of Wild-type recovered-individual sera. e The cross-neutralizing capacity of Delta recovered individual sera. f The cross-neutralizing capacity of Omicron recovered-individual sera. Assessments of cross-neutralizing effect was calculated by normalized mean fluorescence intensity (MFI) of IgG and IgM detected in sera from post-infection individuals. The red dash line indicates the normalized MFI of IgG of control group plus triples of standard deviation. The black line indicates the mean of normalized MFI of IgG. (Control: sera collected before the COVID-19 outbreak (n = 23); Wild-type recovered-individual sera (n = 26); Delta recovered-individual sera (n = 14); Omicron recovered-individual sera (n = 14)