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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: Combination of polythyleneimine regulating autophagy prodrug and Mdr1 siRNA for tumor multidrug resistance

Fig. 2

Preparation, characterization, and stabilities of the nanoassemblies. A Schematic of PP/siRNA/HA nanoassemblies. PP: PEI-PTX conjugates; PP/siRNA: PP with siRNA condensed on the surface; PP/siRNA/HA; PP/siRNA covered with HA. B Gel electrophoresis of PP/siRNA at various weigh ratios (C) The ζ-potential and z-average of PP/siRNA at different ratio of PP and siRNA (D) The ζ-potential and z-average of PP/siRNA/HA at different ratio of PP/siRNA and HA. E TEM images of PP, PP/siRNA, and PP/siRNA/HA; visualized by negative staining with 1% phosphotungstic acid. Scale bars: 100 nm. F Size distribution of PP, PP/siRNA, and PP/siRNA/HA. G Hemolytic toxicity study of PP and PP/HA. H The stabilities of PP/siRNA and PP/siRNA/HA after incubated in 50% FBS. The data are presented as means ± SD

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