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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: Combination of polythyleneimine regulating autophagy prodrug and Mdr1 siRNA for tumor multidrug resistance

Fig. 3

Internalization of nanoassemblies. CLSM images of A549 cells (A) and A549/T cells (B) incubated with naked FAM-siRNA, PP/FAM-siRNA or PP/FAM-siRNA/HA nanoassemblies for 1 h and 4 h. Cell nuclei were stained with DAPI. Scale bars: 50 μm (C) Endocytosis study of PP/siRNA/HA in A549/T cells by Flow cytometry (D) Western blot of P-gp expression in HepG2 cells, A549 cells, and A549/T cells. E Quantitive presentation of Western blotting. F Flow cytometry analysis of uptake in HepG2 cells, A549 cells, and A549/T cells after treated with PP/FAM-siRNA/HA for 4 h. The data are presented as means ± SD. **p < 0.01 and ***p < 0.001

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Journal of Nanobiotechnology

ISSN: 1477-3155

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