Fig. 9

Anti-tumor efficacy of (M + H)@ZIF/HA. A Schematic diagram of (M + H)@ZIF/HA synthesis. B Schematic diagram of (M + H)@ZIF/HA for tumor immunotherapy through multiple pathways including induction of pyroptosis. C Schematic diagram of (M + H)@ZIF/HA in inducing tumor cell pyroptosis and taming MDSC. D Observation of 4T1 cell morphology after different treatments (apoptotic cells: black arrows; pyroptotic cells: white arrows. Scale bar = 10 μm). E Leakage of intracellular content of the LDH after diverse treatments. (F) MGO concentration in MDSCs after different treatments (*p < 0.05, ****p < 0.0001). Reprinted with permission from Ref. [238].