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Fig. 7 | Journal of Nanobiotechnology

Fig. 7

From: Uterine macrophages as treatment targets for therapy of premature rupture of membranes by modified ADSC-EVs through a circRNA/miRNA/NF-κB pathway

Fig. 7

Targeted delivery of F4/80-EVs into macrophages in vivo. A Location of F4/80-EVs in uterine sections from F4/80-EV-treated PROM mice using the corresponding Cy5-labeled secondary antibody of F4/80. A rabbit polyclonal antibody against F4/80 labeled with FITC was used to verify macrophages. Double-positive cells indicated macrophages that carried F4/80-EVs (n = 3). B and C Representative immunofluorescence images of iNOS- and CD206-positive cells in the uteri of PROM mice treated with various F4/80-EVs and quantification of iNOS- and CD206-positive cells in uterine tissues following these treatments (n = 3); *p < 0.05; **p < 0.01; ***p < 0.001; ns, not significant

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