Fig. 8

Biocompatibility and antitumor activity of CMMCP in vivo. a H&E staining sections of heart, liver, spleen, lung, kidney from mice injected CMMP intravenously at 200 mg/kg and control group. b Body weight changes of mice with injection of CMMP at different doses (0, 50, 100, and 200 mg/kg) within 14 days. c Body weight changes of mice from the control group, MW, CDDP, CMMCP and CMMCP + MW groups during the 14-day treatment period. d Tumor volume growth curve in each experimental group for 14 days. e Images of tumors in different groups after 14 days. f H&E staining sections of tumor slices for different groups killed at 14 days. * indicates p < 0.05, ** indicates p < 0.01, *** indicates p < 0.001