Fig. 2
Evaluation of the interactions between UiO-67 conjugates and different cells. A Flow cytometry histogram results of fluorescein-labelled UiO-67 conjugates (Co-UiO-67@Py-PAA-PEG-F3 and Co-UiO-67@Py-PAA-PEG) in nucleolin-positive MDA-MB-231 cells and nucleolin-negative L929 cells. Quantification analysis of normalized mean fluorescence intensity in MDA-MB-231 cells was also shown to confirm the controlling role of F3 conjugation. B The confocal fluorescence microscopy results of fluorescein-labelled UiO-67 conjugates (Co/Ru-UiO-67@Py-PAA-PEG-F3 and Co/Ru-UiO-67@Py-PAA-PEG) in MDA-MB-231 cells (Blue: DAPI, Green: fluorescein-labelled UiO-67 conjugates). C The kinetic evaluation of cell internalization (upper) and efflux (below) behavior of 89Zr-Co/Ru-UiO-67@Py-PAA-PEG-F3 and 89Zr-Co/Ru-UiO-67@Py-PAA-PEG in MDA-MB-231 cells