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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: Intensity-adjustable pain management with prolonged duration based on phase-transitional nanoparticles-assisted ultrasound imaging-guided nerve blockade

Fig. 3

A Optical microscope images of the RLBP nanoparticles after ultrasound irradiation. The scale bar is 25 μm. B CEUS images of the RLBP nanoparticles after ultrasound irradiation at different times. C Quantitative analysis of the sound intensity in the CEUS images. D Schematic illustration of the phase-transitional process of the RLBP nanoparticles with ultrasound irradiation and ultrasound-enhanced levobupivacaine release profile. E Cumulative release of levobupivacaine without ultrasound irradiation. F Cumulative release of levobupivacaine with ultrasound irradiation. G Quantitative levobupivacaine release after each cycle of ultrasound irradiation (n = 5, *p < 0.05, **p < 0.01, compared by Students’ t-test)

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